Transforming Growth Factor β and Connective
Tissue Growth Factor Are Involved in
the Evolution of Nevus of Nanta
Tomoko Keida, Nobukazu Hayashi, Michiko Kawakami and Makoto Kawashima
Abstract
We report a 59-year-old Japanese male with nevus of Nanta on the face. Histological examination revealed a nest of nevus cells in the dermis and ossification beneath the nevus.
Positive staining for transforming growth factor-β and connective tissue growth factor suggested the involvement of these growth factors in the ossification of nevus of Nanta.
Key words:nevus of Nanta; osteoma cutis; cutaneous bone formation; transforming growth factor-β(TGF-β);connective tissue growth factor(CTGF)