Transforming Growth Factor β and Connective Tissue Growth Factor Are Involved in the Evolution of Nevus of Nanta

Transforming Growth Factor β and Connective
Tissue Growth Factor Are Involved in
the Evolution of Nevus of Nanta

Tomoko Keida, Nobukazu Hayashi, Michiko Kawakami and Makoto Kawashima

Abstract

We report a 59-year-old Japanese male with nevus of Nanta on the face. Histological examination revealed a nest of nevus cells in the dermis and ossification beneath the nevus.
Positive staining for transforming growth factor-β and connective tissue growth factor suggested the involvement of these growth factors in the ossification of nevus of Nanta.

Key words:nevus of Nanta; osteoma cutis; cutaneous bone formation; transforming growth factor-β(TGF-β);connective tissue growth factor(CTGF)

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